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2月24日，浙江大学团队在《神经元》（Neuron）发表论文Endogenous retrovirus-derived RNA-DNA hybrids induce microglial synaptic pruning in autism models，报告他们发现内源性逆转录病毒（ERV，一类特殊的逆转座序列，在基因组中拥有大量序列相似的拷贝）衍生的RNA-DNA杂交体诱导自闭症模型中的小胶质细胞突触修剪。研究团队使用已被美国FDA批准用于治疗HIV感染的逆转录酶抑制剂进行早期干预，能够显著抑制ERV的逆转录活性，从源头上减少RNA-DNA杂交体的形成，进而降低补体分子的C4b表达、减轻小胶质细胞的过度修剪，最终挽救小鼠的自闭症核心症状。
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For the uninitiated, the Pocket isn't an emulation machine. It plays actual Game Boy, Game Boy Color and Game Boy Advance cartridges. It also integrates with various Game Boy accessories, like the camera and printer. The console can even handle Game Gear, TurboGrafx-16 and Atari Lynx games, but those require separate adapters.
This is not the only surprise in this article.